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Disease Profile
Soft tissue sarcoma
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
1-5 / 10 000
Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Connective Tissue Sarcoma; Non-Rhabdomyosarcoma soft tissue sarcoma
Categories
Rare Cancers
Summary
Soft
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Olaratumab(Brand name: Lartruvo) Manufactured by Eli Lilly and Company
FDA-approved indication: In combination with doxorubicin, for the treatment of adult patients with softtissue sarcoma (STS) with a histologic subtype for which an anthracycline-containing regimen is appropriate and which is not amenable to curative treatment with radiotherapy or surgery.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Pazopanib(Brand name: Votrient) Manufactured by GlaxoSmithKline
FDA-approved indication: Advanced soft tissue sarcoma (STS) who have received priorchemotherapy .
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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Sarcoma Alliance for Research through Collaboration (SARC)
24 Frank Lloyd Wright Drive
Lobby A, Suite 3100
Ann Arbor, MI 48105
Telephone: +1-734-930-7600
Fax: +1-734-930-7557
E-mail: [email protected]
Website: https://sarctrials.org -
Sarcoma Foundation of America
PO Box 98160
Washington, DC 20090-8160
Telephone: +1-301-253-8687
Fax: +1-301-253-8690
E-mail: [email protected]
Website: https://www.curesarcoma.org/ -
The Liddy Shriver Sarcoma Initiative
17 Bethea Drive
Ossining, NY 10562-1620
Telephone: 914-762-3251
Website: https://sarcomahelp.org/
Organizations Providing General Support
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The Limb Preservation Foundation
925 S Niagara Street
Suite 610
Denver, CO 80224
Telephone: (303) 429-0688
E-mail: [email protected]
Website: https://limbpreservation.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The American Cancer Society provides information on Soft tissue sarcoma. Please click on the link to access this resource.
- Mayo Clinic has an information page on Soft tissue sarcoma.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
In-Depth Information
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
References
- Adult Soft Tissue Sarcoma Treatment (PDQ®)–Health Professional Version. National Cancer Instittute. January 2016; https://www.cancer.gov/types/soft-tissue-sarcoma/hp/adult-soft-tissue-treatment-pdq.
- Soft tissue sarcoma. Mayo Clinic. July 2015; https://www.mayoclinic.org/diseases-conditions/soft-tissue-sarcoma/basics/definition/con-20033386.
- Sarcoma: Adult Soft Tissue Cancer. American Cancer Society. February 2016; https://www.cancer.org/cancer/sarcoma-adultsofttissuecancer/detailedguide/sarcoma-adult-soft-tissue-cancer-soft-tissue-sarcoma.