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Disease Profile
Pityriasis lichenoides chronica
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
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Categories
Skin Diseases
Summary
Pityriasis lichenoides chronica (PLC) is a skin disease that causes the development of small, scaling, raised spots (papules) on the skin. PLC is the relatively mild form of the disease pityriasis lichenoides. A person with PLC tends to have multiple episodes of papules on the skin lasting for months or a few years, meaning the disease is chronic. The papules develop gradually. They first appear pink and scaly, and they gradually flatten and become brown in color over a period of weeks or months. Papules at various stages may be present at any one time.[1]
The cause of PLC is unknown, but it is not contagious. There are several theories about the cause of the disease, including that it may be a response by the
Symptoms
The most common locations for the papules are the trunk, buttocks, arms, and legs. Rarely, the papules may also occur on the hands, feet, face, and scalp. The papules typically are located in groups, and are generally not painful or itchy.[1][3] The papules can resemble those associated with psoriasis, chicken pox, or insect bites.[3]
PLC is a chronic disease, meaning that some people experience the development of new papules after old papules have faded. This can last for several months to several years.[2] PLC most commonly affects adolescents and young adults. The disease may be slightly more common in males.[1][2]
Cause
There is some evidence that PLC could be caused by the overgrowth of
Diagnosis
Treatment
- Exposure to sunlight while carefully avoiding sunburn
- Steroid creams
- Oral
antibiotics - Phototherapy
- Photochemotherapy: a treatment that uses a combination of psoralens and
ultraviolet radiation
If these therapies do not help treat PLC, other treatments may be used including oral steroids and immunosuppressants.[1][2] In some cases, PLC may not respond to treatment, and relapses may occur. If the papules do return, close follow-up with a
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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British Association of Dermatologists
19 Fitzroy Square
London, UK W1T 6EH
United Kingdom
Telephone: 0207 383 0266
Fax: 0207 388 5263
E-mail: [email protected]
Website: https://www.bad.org.uk -
British Skin Foundation
4 Fitzroy Square
London, W1T 5HQ United Kingdom
Telephone: 0207 391 6341
Website: https://www.britishskinfoundation.org.uk/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- The British Association of Dermatologists provides an informational leaflet on pityriasis lichenoides. Click on the British Association of Dermatologists link to view this leaflet.
- DermNet NZ is an online resource about skin diseases developed by the New Zealand Dermatological Society Incorporated. DermNet NZ provides information about this condition.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Pityriasis lichenoides chronica. Click on the link to view a sample search on this topic.
References
- Ngan, V. Pityriasis lichenoides. DermNet NZ. https://www.dermnetnz.org/topics/pityriasis-lichenoides/. Accessed 4/21/2018.
- Haeberie MT and Callen JP. Pityriasis Lichenoides. Medscape. April 17, 2017; https://emedicine.medscape.com/article/1099078-overview.
- Pityriasis Lichenoides. British Association of Dermatologists. September 2016; https://www.bad.org.uk/shared/get-file.ashx?id=115&itemtype=document.
- Khachemoune A and Blyumin ML. Pityriasis lichenoides: pathophysiology, classification, and treatment. Am J Clin Dermatol. 2007; 8(1):29-36. https://www.ncbi.nlm.nih.gov/pubmed/17298104.
- Maranda EL, Smith M, Nguyen AH, Patel VN, Schachner LA, and Joaquin JJ. Phototherapy for Pityriasis Lichenoides in the Pediatric Population: A Review of the Published Literature. Am J Clin Dermatol. December 2016; 17(6):583-591. https://www.ncbi.nlm.nih.gov/pubmed/27502793.
- Zang JB, Coates SJ, Vonderheid EC, and Cohen BA. Pityriasis lichenoides: Long-term follow-up study. Pediatric Dermatology. March 2018; 35(2):213-219. https://www.ncbi.nlm.nih.gov/pubmed/29315771.
- Zaaroura H, Sahar D, Bick T, and Bergman R. Relationship Between Pityriasis Lichenoides and Mycosis Fungoides: A Clinicopathological, Immunohistochemical, and Molecular Study. American Journal of Dermatopathology. November 22, 2017; https://www.ncbi.nlm.nih.gov/pubmed/29210716.
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