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Disease Profile
Essential tremor
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
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Age of onset
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ICD-10
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Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Benign essential tremor; Presenile tremor syndrome; Familial essential tremor;
Categories
Nervous System Diseases
Summary
Essential tremor is the most common movement disorder. It is characterized by involuntary and rhythmic shaking (tremor), especially in the hands, without any other signs or symptoms. It is distinguished from tremor that results from other disorders or known causes, such as tremors seen with Parkinson disease or head trauma.[1][2] Most cases of essential tremor are hereditary. There are five forms of essential tremor that are based on different genetic causes. Several
Cause
Treatment
- Propranolol, a drug that blocks the action of stimulating substances called neurotransmitters, particularly those related to adrenaline
- Primidone, an antiseizure drug that also control the function of some neurotransmitters
These drugs can have significant side effects.[3]
Eliminating tremor "triggers" such as caffeine and other stimulants from the diet is often recommended.
More details about the management of essential tremor can be accessed through the Mayo Clinic and Medscape.
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Supporting this Disease
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International Essential Tremor Foundation (IETF)
P.O. Box 14005
Lenexa, KS 66285-4005
Toll-free: 1-888-387-3667
Telephone: +1-913-341-3880
Fax: +1-913-341-1296
E-mail: [email protected]
Website: https://www.essentialtremor.org -
National Tremor Foundation (NTF)
Harold Wood Polyclinic
St Clement's Avenue
Harold Wood
Essex
RM3 0FE
United Kingdom
Telephone: + 44 (0) 1708 386399
E-mail: [email protected]
Website: https://tremor.org.uk/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MayoClinic.com provides information about essential tremor. Click on the link to view this information.
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- Genetics Home Reference (GHR) contains information on Essential tremor. This website is maintained by the National Library of Medicine.
- The National Institute of Neurological Disorders and Stroke (NINDS) collects and disseminates research information related to neurological disorders. Click on the link to view information on this topic.
- The National Organization for Rare Disorders (NORD) has a report for patients and families about this condition. NORD is a patient advocacy organization for individuals with rare diseases and the organizations that serve them.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- Online Mendelian Inheritance in Man (OMIM) lists the subtypes and associated genes for Essential tremor in a table called Phenotypic Series. Each entry in OMIM includes a summary of related medical articles. It is meant for health care professionals and researchers. OMIM is maintained by Johns Hopkins University School of Medicine.
- Orphanet is a European reference portal for information on rare diseases and orphan drugs. Access to this database is free of charge.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Essential tremor. Click on the link to view a sample search on this topic.
References
- Essential tremor. Genetics Home Reference (GHR). June 2013; https://ghr.nlm.nih.gov/condition/essential-tremor.
- NINDS Essential Tremor Information Page. National Institute of Neurological Disorders and Stroke (NINDS). April 25, 2013; https://www.ninds.nih.gov/Disorders/All-Disorders/Essential-Tremor-Information-Page.
- Essential tremor. MedlinePlus. 2014; https://www.nlm.nih.gov/medlineplus/ency/article/000762.htm.
- Essential tremor. MayoClinic.com. 2013; https://www.mayoclinic.com/print/essential-tremor/DS00367/METHOD=print&DSECTION=all.
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