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5 Facts you should know about
Complement 3 glomerulopathy
1
The term C3 glomerulopathy was adopted by expert consensus in 2013 to define a group of rare kidney diseases driven by dysregulation of the complement cascade
2
C3 glomerulopathy is characterized accumulation of the C3 component of complement in renal tissue
3
There are two major subgroups of C3 glomerulopathy — dense deposit disease (DDD) and C3 glomerulonephritis (C3GN)
4
About 50% of patients with C3G progress to kidney failure within 10 years of diagnosis
5
Factor B, factor D, and properdin (factor P) are specific components of the alternative pathway of complement activation
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