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Disease Profile
Primary liver cancer
Prevalence estimates on Rare Medical Network websites are calculated based on data available from numerous sources, including US and European government statistics, the NIH, Orphanet, and published epidemiologic studies. Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct.
0
Age of onset
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ICD-10
C22.0
Inheritance
Autosomal dominant A pathogenic variant in only one gene copy in each cell is sufficient to cause an autosomal dominant disease.
Autosomal recessive Pathogenic variants in both copies of each gene of the chromosome are needed to cause an autosomal recessive disease and observe the mutant phenotype.
X-linked
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
dominant X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X chromosome.
X-linked
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
recessive Pathogenic variants in both copies of a gene on the X chromosome cause an X-linked recessive disorder.
Mitochondrial or multigenic Mitochondrial genetic disorders can be caused by changes (mutations) in either the mitochondrial DNA or nuclear DNA that lead to dysfunction of the mitochondria and inadequate production of energy.
Multigenic or multifactor Inheritance involving many factors, of which at least one is genetic but none is of overwhelming importance, as in the causation of a disease by multiple genetic and environmental factors.
Not applicable
Other names (AKA)
Primary tumor of the liver; Primary Liver Carcinoma; Primary Malignant Liver Neoplasm;
Categories
Digestive Diseases; Rare Cancers
Treatment
FDA-Approved Treatments
The medication(s) listed below have been approved by the Food and Drug Administration (FDA) as orphan products for treatment of this condition. Learn more orphan products.
- Cabozantinib(Brand name: Cabometyx) Manufactured by Exelixis, Inc.
FDA-approved indication: January 2019, cabozantinib (Cabometyx) was approved for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Lenvatinib(Brand name: Lenvima) Manufactured by Eisai Inc.
FDA-approved indication: August 2018, lenvatimib (Lenvima) was approved for the first-line treatment of patients with unresectable hepatocellular carcinoma (HCC).
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Ethiodized oil injection(Brand name: Lipiodol) Manufactured by Guerbet LLC
FDA-approved indication: September 2013, ethiodized oil injection (Lipiodol) was approved for selective hepatic intra-arterial use forimaging tumors in adults with known hepatocellular carcinoma (HCC).
National Library of Medicine Drug Information Portal - Sorafenib(Brand name: Nexavar) Manufactured by Bayer Pharmaceutical Corporation
FDA-approved indication: April 2006, sorafenib (Nexavar) was approved for the treatment of unresectable hepatocellular carcinoma.
National Library of Medicine Drug Information Portal
Medline Plus Health Information - Regorafenib(Brand name: Stivarga) Manufactured by Bayer HealthCare Pharmaceuticals
FDA-approved indication: April 2017, regorafenib (Stivarga) was approved for the treatment of patients with hepatocellular carcinoma (HCC or livercancer ) who have been previously treated with the drug sorafenib.
National Library of Medicine Drug Information Portal
Medline Plus Health Information
Organizations
Support and advocacy groups can help you connect with other patients and families, and they can provide valuable services. Many develop patient-centered information and are the driving force behind research for better treatments and possible cures. They can direct you to research, resources, and services. Many organizations also have experts who serve as medical advisors or provide lists of doctors/clinics. Visit the group’s website or contact them to learn about the services they offer. Inclusion on this list is not an endorsement by GARD.
Organizations Providing General Support
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American Association for the Study of Liver Diseases
1001 North Fairfax, 4th floor
Alexandria, VA 22314
Telephone: 703–299–9766
Fax: 703–299–9622
E-mail: [email protected]
Website: https://www.aasld.org/ -
American Cancer Society
250 Williams Street NW
Atlanta, GA 30329
Toll-free: 1-800-227-2345
Website: https://www.cancer.org -
American Liver Foundation
39 Broadway, Suite 2700
New York, NY 10006
Toll-free: +1-800-465-4837 (Helpline)
Telephone: +1-212-668-1000
E-mail: https://liverfoundation.org/for-patients/contact-us/
Website: https://liverfoundation.org/
Learn more
These resources provide more information about this condition or associated symptoms. The in-depth resources contain medical and scientific language that may be hard to understand. You may want to review these resources with a medical professional.
Where to Start
- MedlinePlus was designed by the National Library of Medicine to help you research your health questions, and it provides more information about this topic.
- The Merck Manuals Online Medical Library provides information on this condition for patients and caregivers.
- The National Cancer Institute provides the most current information on cancer for patients, health professionals, and the general public.
- The National Kidney and Urologic Diseases Information Clearinghouse (NIDDK) conducts and supports research on a broad spectrum of diseases affecting public health. Click on the link to view information on this topic.
In-Depth Information
- Medscape Reference provides information on this topic. You may need to register to view the medical textbook, but registration is free.
- The Monarch Initiative brings together data about this condition from humans and other species to help physicians and biomedical researchers. Monarch’s tools are designed to make it easier to compare the signs and symptoms (phenotypes) of different diseases and discover common features. This initiative is a collaboration between several academic institutions across the world and is funded by the National Institutes of Health. Visit the website to explore the biology of this condition.
- PubMed is a searchable database of medical literature and lists journal articles that discuss Primary liver cancer. Click on the link to view a sample search on this topic.